The example below shows how to make a PDF with AdobePhotoshop CS4. 

Bleed Requirements

Please make sure that your document contains a bleed.  Bleeds of 1/8″ are required on anything small like business cards, flyers, brochures, sell sheets, newsletters, or booklets. For larger items, such as signs, posters, tradeshow graphics, and the like, 1/4″ bleeds are needed. Once you determine which type of product you are printing, make sure you account for the correct bleed when setting up your file.

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To save the file as a PDF:

• Choose File > Save As and then choose Photoshop PDF (it is highly recommended to have Layers box checked)

• From Presets, choose [Press Quality]

• Next Click Compression (left menu) and make sure the lowest compression is at 300ppi and not below. 

• Use JPEG compression, High Quality, for all images

• Give your File a name and click Save

• Always verify that the PDF exported properly by opening it in Adobe Acrobat or Adobe Reader.